Create2Solve grant

6 december 2023

In May 2023, LymphChip organized Helpathon #8 asking help to find animal-free alternatives for serum and Matrigel. As a direct result of this Helpathon, an application was submitted to the Create2Solve Phase 1 call of ZonMw to optimize and standardize methods to produce serum and Matrigel free iPSC derived immune competent intestine: Immuno-Gut.

Immuno-Gut got granted and the aim is to develop methods and carry out an and inter-laboratory validation study to obtain robust data for animal free production of immune competent iPSC derived intestine organoids. In Phase 1 products will be tested which do not contain Matrigel and FCS. The most promising, and where possible, totally xeno-free products will be selected for further validation in an inter-laboratory study in Phase 2.

Sue Gibbs and Valeria Orlova with help from BioTechne, Miltenyi, Stem Cell Technologies, three companies that participated in the Helpathon as well as NCardia will work together in Phase 1.

For more information see: https://www.zonmw.nl/en/news/6-project-groups-take-challenges-develop-animal-free-innovations

Meer nieuws

First LymphChip PhD Thesis: Tomas van Dorp successfully defended his thesis on vascularized heart-on-chip models

2 juli 2026

On July 2, Tomas van Dorp of Twente University successfully defended his thesis entitled: “The development of vascularized heart-on-chip models”. Tomas is the first PhD student graduating from the LymphChip consortium. For more detailed information on his research please see: https://www.utwente.nl/en/tnw/events/2026/7/941394/phd-defence-tomas-van-dorp-the-development-of-vascularized-heart-on-chip-models?code=d5ec76f7

Cuore workshop

21 april 2026

On the 16th of April, the Leiden Organ-on-Chip Center and Optics11 Life organized a workshop focused on the “Cuore” platform at Mirai House in Leiden. This platform was developed by Optics11 Life and enables contractility measurements of 3D engineered muscle tissues, including cardiac, skeletal and smooth muscle tissue. Optics11 Life talked about the capabilities and potential […]

Webinars Fluigent

16 februari 2026

Following the development of an application note developed in collaboration with the Leiden Organ-on-Chip Center, Fluigent will host a webinar on the topic of flow in Organ-on-Chip models and vascular in vitro modeling. Application note authors Dr. Valeria Orlova and Dr. Dhanesh Kasi from the LUMC will share their insights into vessel-on-chip modelling under dynamic flow conditions, with a […]