Create2Solve grant

december 6, 2023

In May 2023, LymphChip organized Helpathon #8 asking help to find animal-free alternatives for serum and Matrigel. As a direct result of this Helpathon, an application was submitted to the Create2Solve Phase 1 call of ZonMw to optimize and standardize methods to produce serum and Matrigel free iPSC derived immune competent intestine: Immuno-Gut.

Immuno-Gut got granted and the aim is to develop methods and carry out an and inter-laboratory validation study to obtain robust data for animal free production of immune competent iPSC derived intestine organoids. In Phase 1 products will be tested which do not contain Matrigel and FCS. The most promising, and where possible, totally xeno-free products will be selected for further validation in an inter-laboratory study in Phase 2.

Sue Gibbs and Valeria Orlova with help from BioTechne, Miltenyi, Stem Cell Technologies, three companies that participated in the Helpathon as well as NCardia will work together in Phase 1.

For more information see: https://www.zonmw.nl/en/news/6-project-groups-take-challenges-develop-animal-free-innovations

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Application Note Fluigent

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Flow conditions and a stable well-defined flow direction are important to culture in vivo-like endothelial cells over time that maintain their organization and function. With help of Dhanesh Khasi, Hanna Lammertse and Valeria Orlova, an application note was put together by Fluigent describing the proper conditions for hiPSCs-derived vascular organ-on-chip model under unidirectional controlled flow: https://www.fluigent.com/resources-support/expertise/application-notes/hipscs-derived-vascular-organ-on-chip

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januari 16, 2026

Peerlogic is a tool to facilitate animal-free cell culturing. To this end protocols and Materials & Methods sections for xeno-free & FCS-free cell culturing are being shared as well as animal-free alternatives to basement membrane extracts (BME) such as Matrigel. With this tool we want to stimulate collaboration and through peer review we want to […]