In May 2023, LymphChip organized Helpathon #8 asking help to find animal-free alternatives for serum and Matrigel. As a direct result of this Helpathon, an application was submitted to the Create2Solve Phase 1 call of ZonMw to optimize and standardize methods to produce serum and Matrigel free iPSC derived immune competent intestine: Immuno-Gut.
Immuno-Gut got granted and the aim is to develop methods and carry out an and inter-laboratory validation study to obtain robust data for animal free production of immune competent iPSC derived intestine organoids. In Phase 1 products will be tested which do not contain Matrigel and FCS. The most promising, and where possible, totally xeno-free products will be selected for further validation in an inter-laboratory study in Phase 2.
Sue Gibbs and Valeria Orlova with help from BioTechne, Miltenyi, Stem Cell Technologies, three companies that participated in the Helpathon as well as NCardia will work together in Phase 1.
For more information see: https://www.zonmw.nl/en/news/6-project-groups-take-challenges-develop-animal-free-innovations