
Paraxial mesoderm as a direct gateway to lymphatic endothelial cells
January 16, 2025
Valeria Orlova and Tatiana Petrova have published a paper in Nature Cardiovascular Research in which the origins of mammalian lymphatic vessels have been studied. In conclusion, the centripetal model via the paraxial mesoderm lineage may offer a more promising approach for direct differentiation of LECS in vitro without the need to pass through an intermediate venous lineage via the centrifugal model.
The link to the full publication is: https://rdcu.be/d5ovE
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Webinars Fluigent
February 16, 2026
Following the development of an application note developed in collaboration with the Leiden Organ-on-Chip Center, Fluigent will host a webinar on the topic of flow in Organ-on-Chip models and vascular in vitro modeling. Application note authors Dr. Valeria Orlova and Dr. Dhanesh Kasi from the LUMC will share their insights into vessel-on-chip modelling under dynamic flow conditions, with a […]

Application Note Fluigent
January 27, 2026
Flow conditions and a stable well-defined flow direction are important to culture in vivo-like endothelial cells over time that maintain their organization and function. With help of Dhanesh Khasi, Hanna Lammertse and Valeria Orlova, an application note was put together by Fluigent describing the proper conditions for hiPSCs-derived vascular organ-on-chip model under unidirectional controlled flow: https://www.fluigent.com/resources-support/expertise/application-notes/hipscs-derived-vascular-organ-on-chip

Strategic Workshops Catalyze
January 20, 2026
As part of our aim to identify opportunities for valorization, Catalyze gave two Strategic Workshops on January 20. The first workshop was aimed at LymphChip PIs and their senior colleagues and concentrated on the first steps to translate a (scientific) innovation/tool into a marketable product. In the second workshop options for future funding for LymphChip […]