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Paraxial mesoderm as a direct gateway to lymphatic endothelial cells

January 16, 2025

Valeria Orlova and Tatiana Petrova have published a paper in Nature Cardiovascular Research in which the origins of mammalian lymphatic vessels have been studied. In conclusion, the centripetal model via the paraxial mesoderm lineage may offer a more promising approach for direct differentiation of LECS in vitro without the need to pass through an intermediate venous lineage via the centrifugal model.

The link to the full publication is: https://rdcu.be/d5ovE

More news

July 2, 2026

On July 2, Tomas van Dorp of Twente University successfully defended his thesis entitled: “The development of vascularized heart-on-chip models”. Tomas is the first PhD student graduating from the LymphChip consortium. For more detailed information on his research please see: https://www.utwente.nl/en/tnw/events/2026/7/941394/phd-defence-tomas-van-dorp-the-development-of-vascularized-heart-on-chip-models?code=d5ec76f7

Cuore workshop
April 21, 2026

On the 16th of April, the Leiden Organ-on-Chip Center and Optics11 Life organized a workshop focused on the “Cuore” platform at Mirai House in Leiden. This platform was developed by Optics11 Life and enables contractility measurements of 3D engineered muscle tissues, including cardiac, skeletal and smooth muscle tissue. Optics11 Life talked about the capabilities and potential […]

February 16, 2026

Following the development of an application note developed in collaboration with the Leiden Organ-on-Chip Center, Fluigent will host a webinar on the topic of flow in Organ-on-Chip models and vascular in vitro modeling. Application note authors Dr. Valeria Orlova and Dr. Dhanesh Kasi from the LUMC will share their insights into vessel-on-chip modelling under dynamic flow conditions, with a […]