
Monitoring organs-on-chip: a story by Massimo Mastrangeli
This year Massimo Mastrangeli was appointed as Associate Professor at TU Delft.
In his research he exploits his knowledge on microelectronics to create a home for human cells outside the human body. With a combination of soft and hard materials an environment is created to host cells or tissues, the chip. Stimulation of these cells or tissues with electricity, motion, mechanical power and chemicals allow them to grow and mature and function as a mini organ. Moreover, the chips are equipped to record signals to monitor the cells and tissues. To be able to see what is happening inside the chip the materials need to be transparent. The resulting organs-on-chips consist of human material and are therefore expected to be better predictors than animals for instance in drug development and toxicity studies.
Please check this link for the full story of Massimo
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Cuore workshop
On the 16th of April, the Leiden Organ-on-Chip Center and Optics11 Life organized a workshop focused on the “Cuore” platform at Mirai House in Leiden. This platform was developed by Optics11 Life and enables contractility measurements of 3D engineered muscle tissues, including cardiac, skeletal and smooth muscle tissue. Optics11 Life talked about the capabilities and potential […]

Webinars Fluigent
Following the development of an application note developed in collaboration with the Leiden Organ-on-Chip Center, Fluigent will host a webinar on the topic of flow in Organ-on-Chip models and vascular in vitro modeling. Application note authors Dr. Valeria Orlova and Dr. Dhanesh Kasi from the LUMC will share their insights into vessel-on-chip modelling under dynamic flow conditions, with a […]

Application Note Fluigent
Flow conditions and a stable well-defined flow direction are important to culture in vivo-like endothelial cells over time that maintain their organization and function. With help of Dhanesh Khasi, Hanna Lammertse and Valeria Orlova, an application note was put together by Fluigent describing the proper conditions for hiPSCs-derived vascular organ-on-chip model under unidirectional controlled flow: https://www.fluigent.com/resources-support/expertise/application-notes/hipscs-derived-vascular-organ-on-chip